Sleep patterns can help predict bipolar in at-risk offspring
August 10, 2021, PELOTAS, Brazil—Sleep patterns can help to identify if someone with a parent with bipolar disorder is at increased risk of developing the disorder, new research suggests.
Brazilian researchers analyzed studies on the topic and found that the bipolar offspring showed greater daytime sleepiness, and that shorter sleep duration, sleep disorders and other related features can differentiate the two groups.
The study also found some sleep patterns such as decreased sleep, difficulty falling asleep, and overall sleep problems might be predictors for the development of bipolar disorder.
The study, which appeared in the journal Trends in Psychiatry and Psychotherapy online ahead of print, was entitled “Sleep alterations as a predictor of bipolar disorder among offspring of parents with bipolar disorder: A systematic review and meta-analysis.”
Poor sleep associated with impaired executive functioning
October 1, 2021, ANN ARBOUR, MI—People with bipolar I disorder who are experiencing poor sleep may be more vulnerable to impairments of verbal learning and executive functioning, a new study suggests.
American researchers noted that poor sleep has been associated with more severe clinical features in bipolar disorder. In addition, poor sleep has been shown to adversely affect learning, memory, and executive functioning in individuals in the general population.
They said, less is known about whether the correlation between poor sleep and poorer neuropsychological functioning holds true for people with bipolar disorder. Neuropsychological functions include attention and memory, problem-solving, verbal and visual-spatial abilities, sensory perception, and motor control, as well as mood and emotion.
The study authors found the effects of poor sleep on neuropsychological functioning did not differ significantly between the two groups. Overall, poor sleep was linked most strongly to deficits in verbal learning, verbal fluency, processing speed (how quickly mental tasks are performed, such as reacting to new information), and interference control (the ability to override impulsivity for a better outcome).
However, the group with bipolar reported poorer sleep quality than the control group.
The study, which appeared in the Journal of Affective Disorders, was entitled “Sleep quality and neuropsychological functioning in bipolar I disorder.”
ADHD possible risk factor for developing bipolar in youth
October 1, 2021, PISA, Italy—Children and teens with attention-deficit/hyperactivity disorder (ADHD) appear to be at higher risk of developing bipolar disorder than their peers in the general population, a new study suggests.
Italian researchers noted increasing interest in identifying precursors of bipolar to facilitate early intervention and treatment. Symptoms of ADHD are among the most common prodromal (or pre-onset) symptoms of the mood disorder.
The researchers analyzed 10 studies involving more than 1,200 young people with ADHD and estimated that 10 percent developed bipolar. They said greater clinical attention should be paid to children and teens diagnosed with ADHD to detect possible mood disorder symptoms.
The study, which appeared in the Journal of Affective Disorders, was entitled “Development of bipolar disorder in patients with attention-deficit/hyperactivity disorder: A systematic review and meta-analysis of prospective studies.”
Depressive disorder risk factor for new-onset bipolar in young adults
September 1, 2021, PORTO ALEGRE, Brazil—A new study assessing risk factors for new-onset bipolar disorder in young adults has identified depressive episodes as the strongest marker.
Brazilian and Canadian researchers looked at more than 1,000 young adults ages 18 to 24 over five years and found the cumulative incidence of bipolar disorder was 4.6 per cent.
Other significant factors associated with higher risk of bipolar onset: anxiety, post-traumatic stress, and tobacco and substance use or dependence.
The study, which appeared in the journal Psychiatry Research, was entitled “Risk factors for new-onset bipolar disorder in a community cohort: A five-year follow up study.”
Antidepressant use common during remission
September 1, 2021, MILAN, Italy—About a third of people with bipolar disorder maintain antidepressant use between acute mood episodes, according to a new study.
Italian and American researchers, noting the treatment guidelines recommend cautious use of antidepressants in bipolar treatment, looked at data on people with bipolar I and II in remission.
They found that among people with bipolar I, maintenance antidepressant use was most common in those whose bipolar first presented with a depressive episode and those whose most recent mood polarity was depressive.
While the authors cautioned that the use of antidepressants could be explained by other co-existing conditions such as anxiety or eating disorders, they said their findings shed light on the need for wider and more specific studies on the use of antidepressants in treating bipolar disorders.
The study, which appeared in the Journal of Affective Disorders, was entitled “Antidepressants in bipolar disorder: Analysis of correlates overall, and in BD-I and BD-II subsamples.”
Higher risk of physical diseases in bipolar
September 1, 2021, COPENHAGEN, Denmark—Compared to the general population, people with bipolar disorder are 1.5 times more likely to be hospitalized for certain medical conditions, a new study has found.
Danish researchers looked at adults with bipolar and other affective disorders who had received hospital treatment for cardiovascular disease, diabetes, cancers, chronic obstructive pulmonary disease (COPD), asthma, inflammatory bowel disease, hip fracture, psoriasis, migraine, or dementia.
While people with bipolar had elevated risk across the range of diseases compared to a control group without any affective disorder, the highest risk associations were for dementia, hip fracture, COPD, and stroke.
The study, which appeared in the Journal of Affective Disorders, was entitled “An analysis of the relative and absolute incidence of somatic morbidity in patients with affective disorders – A nationwide cohort study.”
Impulsivity, hostility may contribute to non-adherence
August 31, 2021, SEOL, South Korea—A new study suggests impulsivity, disinhibition, and hostility may contribute to people with bipolar disorder discontinuing treatment.
South Korean researchers looked at the treatment records of people with bipolar, major depressive disorder and anxiety disorders and major depressive disorder at 10 years after diagnosis. They analyzed how many dropped out of outpatient care within 6 months, how many continued treatment for at least 36 months, and how many stayed in treatment for longer than three years.
People who continued treatment tended to have a higher education and significantly lower hypomania scores. The study authors concluded that compromised ability to weigh risks and consequences, which is common in hypomania, affects treatment adherence.
The study, which appeared in the journal Clinical Psychopharmacology and Neuroscience, was entitled “Patient factors influencing outpatient retention in patients with affective and anxiety disorders: A retrospective study.”
Internet gaming disorder predicts bipolar in university students
August 1, 2021, STANFORD, CA—Internet gaming disorder may be a predictor of bipolar disorder in college students, a new study suggests.
American researchers looked at associations between internet gaming disorder and sleep impairment, daytime functioning, psychiatric disorders, and health status among young adults living in student housing on campus.
Students were considered to have internet gaming disorder if they engaged in recreational pursuits on an electronic device for 15 or more hours a week and displayed five or more addiction-related symptoms. Around 5 percent of the cohort met both criteria, although 40 percent spent at least 15 hours playing on their devices.
The study found students with internet gaming disorder were roughly three times more likely to have major depressive disorder, social anxiety disorder, and a history of suicidal thoughts. Internet gaming disorder also predicted bipolar disorder, excessive fatigue, fewer close friends, depressive mood, non-restorative sleep, and poor to fair health status.
The study, which appeared in the journal Psychiatry Research, was entitled “Internet gaming disorder and comorbidities among campus-dwelling U.S. university students.”
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